In my collection I have several games that may fit into this category and trying to pick one has been a bit of a nightmare.  For some Star Wars seems to fill this niche, for others it is Serenity.

There is only really one game that I was happy to see licensed and that is that awesome Ghostbusters RPG. A very simple rules light system coupled with some really awesome adventures and you all play Ghostbusters!  The published adventures were a hoot to play and packed full of the atmosphere of the first movie.

I think it’s a real shame that such a gem of a game is long out of print although there is a spiritual successor in the form of InSperctres.  There used to be a homepage for this game but it looks like it has vanished, rpgnow looks like the only place to get the game these days.